- Unique library design allows more relevant screening
- Reflects the human pre-immune diversity
- Mimics V-D-J and V-J recombination processes
- Large numbers of unique IgGs
- Very broad epitope coverage

Fully Human Antibody Library
Adimab’s library design philosophy is unique and represents a major advance in the design of fully human antibody repertoires.  Unlike other commercial libraries, Adimab’s libraries have been designed to explicitly account for the recombination of immunoglobulin gene segments (i.e., V, D, and J) recreating natural human pre-immune antibody diversity.  This critical technical feature allows identification of fully human IgGs against many human targets that would otherwise be refractory due to tolerance. All Adimab libraries are constructed by synthetic methods to recapitulate our proprietary in silico design.  A rigorous QC process demonstrates a precise correspondence to the human pre-immune repertoire in terms of length, composition, and sequence information.

Large Diversity
Collectively Adimab’s antibody libraries have a theoretical diversity in excess of 10¹⁴.  In a typical campaign, Adimab screens over 10¹⁰ unique, fully human IgGs from multiple libraries representing different human germlines (“sub-libraries”).  Our approach assures the interrogation of multiple canonical structures, and typically yields hundreds of unique IgGs, with broad diversity in sequence and structure, against numerous targets.

Large Numbers of Binders per Target
Adimab selection campaigns have generated large numbers of fully human IgGs (100’s up to 1000’s) to all targets screened to date.  This is a significant improvement over established technologies (e.g., phage display), that are limited in their ability to sample a large binding space due to the expression system (E.coli) used in the early discovery process (Burton et al., 2007).  In addition, Adimab has shown that each sub-library has no overlap with other sub-libraries when screened against the same target.